Synopsis of Project Aims
This project develops next-generation cell-active bioinks for both volumetric and extrusion-based bioprinting to enable rapid fabrication of biologically functional and vascularized 3D tissue constructs. These materials support high cell survival, migration, and organization while promoting endothelial network formation and tissue integration.
The work addresses two central limitations in bioprinting: the trade-off between print fidelity and biological performance in photocurable systems, and the lack of robust vascularization in engineered tissues.
Approach
- Development of hybrid bioinks enabling cell–matrix interactions across printing modalities
- Optimization for rapid, single-step volumetric fabrication and extrusion compatibility
- Engineering matrices that support cell spreading, migration, and endothelial organization
- Fabrication of multicellular 3D constructs with controlled architecture and cell distribution
- Quantitative evaluation of vascular-like network formation and tissue function
Why This Matters
Current bioinks often achieve either printability or biological performance—but rarely both—and insufficient vascularization remains a major barrier to tissue viability and scalability.
This project bridges these gaps by enabling fast fabrication of biologically active, vascularized constructs, improving mass transport, long-term function, and the physiological relevance of engineered tissues for research and translational applications.
Project Team:
- Jagoda Litowczenko-Cybulska
- San Seint Seint Aye
- MSc Urszula Zgórzyńska
- MSc Julia Góral-Kucińska
- Marta Przymuszałą
- Adelajda Flont
- Roy Siegelmann
- Tolga Durak