Synopsis of project aims
This project develops vascular and cardiac grafts using hybrid extrusion and volumetric bioprinting to enable fabrication of mechanically stable, perfusable, and biologically functional tissue constructs.
It addresses a key limitation in cardiovascular tissue engineering: the lack of constructs capable of long-term integration, remodeling, and coordinated multicellular function.
Approach
- Hybrid biofabrication combining extrusion and volumetric bioprinting
- Design of composite bioinks for controlled mechanics and cell–matrix interactions
- Engineering of multicellular constructs with iPSC-derived cardiomyocytes, smooth muscle cells, and endothelial cells
- Integration with perfusion bioreactor systems for functional maturation
Why This Matters
Current grafts suffer from poor integration and long-term performance. This project enables cell-integrated, perfusable vascular and cardiac constructs that better replicate native tissue function and support development of predictive in vitro models.
Project Team:
- Jagoda Litowczenko-Cybulska
- San Seint Seint Aye
- Marta Przymuszałą
- Adelajda Flont
- Roy Siegelmann
- Tolga Durak